ChloroquineV1, France, Analysis, bibRecord, 000369

New bromoditerpenes from the red alga Sphaerococcus coronopifolius.

Identifieur interne : 000369 ( France/Analysis ); précédent : 000368; suivant : 000370

New bromoditerpenes from the red alga Sphaerococcus coronopifolius.

Auteurs : S. Etahiri ; V. Bultel-Poncé [France] ; Christophe Caux [France] ; M. Guyot [France]

Source :

Journal of Natural Products [ 0163-3864 ] ; 2001-08.

RBID : Hal:hal-00086390

Abstract

The organic extract of the red alga Sphaerococcus coronopifolius, collected along the Atlantic coast of Morocco, was tested for biological activities and exhibited antibiotic and antimalarial activities. Two new bromoditerpenes have been isolated from S. coronopifolius, sphaerolabdadiene-3,14-diol (1) and bromosphaerone (2), along with the known compounds 12S-hydroxybromosphaerodiol (3) and sphaerococcenol A (4). Bromosphaerone and 12S-hydroxybromosphaerodiol showed antibacterial activity against the Gram-positive bacterium species Staphylococcus aureus with a minimum inhibitory concentration of 0.104 and 0.146 μM, respectively. Sphaerococcenol A (4) was responsible for the antimalarial activity of the extract, against the chloroquine resistant Plasmodium falsciparum FCB1 strains with an IC50 of 1 μM. Their structures have been assigned using 1 and 2 D NMR and HRMS.

Url:

https://hal.archives-ouvertes.fr/hal-00086390

DOI: 10.1021/np0002684

Affiliations:

France

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000173
to stream Hal, to step Curation: 000173
to stream Hal, to step Checkpoint: 000248
to stream Main, to step Merge: 002279
to stream Main, to step Curation: 002255
to stream Main, to step Exploration: 002255
to stream France, to step Extraction: 000369

Links to Exploration step

Hal:hal-00086390

Le document en format XML

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<front><div type="abstract" xml:lang="en">              <p>The organic extract of the red alga Sphaerococcus coronopifolius, collected along the Atlantic coast of Morocco, was tested for biological activities and exhibited antibiotic and antimalarial activities. Two new bromoditerpenes have been isolated from S. coronopifolius, sphaerolabdadiene-3,14-diol (1) and bromosphaerone (2), along with the known compounds 12S-hydroxybromosphaerodiol (3) and sphaerococcenol A (4). Bromosphaerone and 12S-hydroxybromosphaerodiol showed antibacterial activity against the Gram-positive bacterium species Staphylococcus aureus with a minimum inhibitory concentration of 0.104 and 0.146 μM, respectively. Sphaerococcenol A (4) was responsible for the antimalarial activity of the extract, against the chloroquine resistant Plasmodium falsciparum FCB1 strains with an IC50 of 1 μM. Their structures have been assigned using 1 and 2 D NMR and HRMS.</p>
            </div>
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{{Explor lien
   |wiki=    Sante
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   |étape=   Analysis
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   |clé=     Hal:hal-00086390
   |texte=   New bromoditerpenes from the red alga Sphaerococcus coronopifolius.
}}

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New bromoditerpenes from the red alga Sphaerococcus coronopifolius.

New bromoditerpenes from the red alga Sphaerococcus coronopifolius.

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri